Chemical Specifications
| CAS Number | 910463-68-2 |
|---|---|
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.64 g/mol |
| Purity (HPLC) | ≥ 99.0% |
| Appearance | White Lyophilized Powder |
| Storage | Store at -20°C |
* This product is intended for laboratory research purposes only and is not for human consumption.
What is Semaglutide?
Semaglutide (2mg – 50mg Vials) is a highly potent, synthetic analog of the naturally occurring human glucagon-like peptide-1 (GLP-1) hormone. This specific receptor agonist has been structurally modified to resist enzymatic degradation, offering a remarkably extended half-life. It serves as a critical, high-grade compound for research models investigating complex metabolic pathways, advanced glycemic control mechanisms, and central appetite regulation across various in-vitro and in-vivo applications.
Key Features & Research Benefits
Body Mass & Weight Reduction
Demonstrates profound efficacy in research models for reducing overall body mass. By significantly delaying gastric emptying and suppressing caloric intake signaling, it serves as a premier compound for studying obesity, metabolic syndrome, and targeted adipose tissue reduction.
Neurological Satiety Signaling
Effectively crosses the blood-brain barrier in test models to interact with the hypothalamus. This allows researchers to accurately observe the modulation of central nervous system pathways, the suppression of appetite-stimulating neurons, and the overall impact on energy expenditure.
Advanced Glycemic Modulation
Demonstrates a powerful, glucose-dependent mechanism of action. It provides researchers with a highly stable compound to study the stimulation of insulin secretion from pancreatic beta cells, alongside the simultaneous suppression of glucagon release.
Extended Half-Life (DPP-4 Resistance)
Engineered with a specific amino acid substitution and the attachment of a C-18 fatty acid chain. This precise structural design heavily shields the peptide from rapid degradation by the DPP-4 enzyme, allowing for prolonged observation periods and less frequent dosing.
Verified High Purity (≥99.0% HPLC)
Synthesized utilizing state-of-the-art solid-phase peptide synthesis (SPPS) and rigorously purified. This guarantees exceptional batch-to-batch consistency and ensures that observed cellular responses are directly attributable to the Semaglutide molecule itself.
Premium Lyophilized Stability
Delivered as a sterile, freeze-dried powder. The lyophilization process protects the fragile peptide bonds from hydrolysis during transit. Once maintained at -20°C, it ensures maximum shelf-life until you are ready to reconstitute it with bacteriostatic water.
How It Works
Semaglutide operates as an advanced, long-acting Glucagon-Like Peptide-1 (GLP-1) receptor agonist. In biological models, it works by closely mimicking the naturally occurring incretin hormone GLP-1, binding directly to and activating the GLP-1 receptor with exceptional affinity.
Once activated, it triggers a multi-faceted cascade of biological responses. First, it powerfully stimulates glucose-dependent insulin secretion from pancreatic beta cells while simultaneously suppressing the inappropriate release of glucagon from alpha cells. This dual-action mechanism ensures highly stable glycemic control. Secondly, it significantly delays gastric emptying, altering the rate at which nutrients are absorbed into the bloodstream, which is a key factor in extending periods of satiety.
Beyond the gastrointestinal tract, Semaglutide is highly notable for its ability to cross the blood-brain barrier and interact directly with specific neurological pathways in the hypothalamus—the brain’s primary hunger-regulation center. Here, it effectively amplifies satiety signals (the feeling of fullness) and heavily suppresses appetite-stimulating neurons, leading to a profound reduction in caloric intake and overall body mass over time.
What sets Semaglutide apart from native GLP-1 is its advanced structural engineering. By substituting a key amino acid at position 8 and attaching a complex C-18 fatty acid chain, it achieves a high degree of binding to albumin in the bloodstream. This critical modification provides near-total resistance to degradation by the dipeptidyl peptidase-4 (DPP-4) enzyme, drastically reducing its metabolic clearance rate and extending its half-life to provide prolonged, steady effects.
🧪 What’s In The Vial
- Active Peptide: Highly Purified Semaglutide
- State: Sterile, Lyophilized Powder
- Format: Multi-dose Research Vial
- Net Contents: As selected (e.g., 2mg to 50mg)
- Purity: ≥99.0% (HPLC)
👩🔬 Who Uses It
- Metabolic Disease Researchers
- Obesity & Weight Management Labs
- Endocrinology Specialists
- Biomedical Scientists
- Clinical Trial Administrators
🔗 Best Paired With
- Sterile Bacteriostatic Water (BAC)
- Precision Laboratory Pipettes
- Calibrated Insulin Syringes
- Vial Storage Organizers (-20°C)
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